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| 1st(1st leg) | Atlético San Luis | - | UANL Tigres | -:- |
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| 2nd (2nd leg) | UANL Tigres | - | Atlético San Luis | -:- |
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| 1st(1st leg): 28/11/2024 | 2nd (2nd leg): 01/12/2024 | |||||
| 1st(1st leg) | CF Monterrey | - | Pumas UNAM | -:- |
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| 2nd (2nd leg) | Pumas UNAM | - | CF Monterrey | -:- |
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| 1st(1st leg): 28/11/2024 | 2nd (2nd leg): 01/12/2024 | |||||
| 1st(1st leg) | Club Tijuana | - | Cruz Azul | -:- |
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| 2nd (2nd leg) | Cruz Azul | - | Club Tijuana | -:- |
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| 1st(1st leg): 28/11/2024 | 2nd (2nd leg): 01/12/2024 | |||||
| 1st(1st leg) | CF América | - | Deportivo Toluca | -:- |
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| 2nd (2nd leg) | Deportivo Toluca | - | CF América | -:- |
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| 1st(1st leg): 28/11/2024 | 2nd (2nd leg): 01/12/2024 | |||||
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