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| 1st(1st leg) | Puebla FC | - | CF América | 1:6 (1:2) | ||
| 2nd (2nd leg) | CF América | - | Puebla FC | 5:1 (2:1) | ||
| 1st(1st leg): 13/10/2022 01:06 | 2nd (2nd leg): 16/10/2022 02:06 | Winner: CF América | ||||
| 1st(1st leg) | Cruz Azul | - | CF Monterrey | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Cruz Azul | 3:0 (1:0) | ||
| 1st(1st leg): 13/10/2022 03:06 | 2nd (2nd leg): 16/10/2022 00:06 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Deportivo Toluca | - | Santos Laguna | 4:3 (2:2) | ||
| 2nd (2nd leg) | Santos Laguna | - | Deportivo Toluca | 1:2 (0:0) | ||
| 1st(1st leg): 14/10/2022 01:06 | 2nd (2nd leg): 17/10/2022 01:06 | Winner: Deportivo Toluca | ||||
| 1st(1st leg) | UANL Tigres | - | CF Pachuca | 1:0 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | UANL Tigres | 2:1 (1:0) | ||
| 1st(1st leg): 14/10/2022 03:06 | 2nd (2nd leg): 17/10/2022 03:06 | Winner: UANL Tigres | ||||
