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| 1st(1st leg) | Deportivo Toluca | - | CF América | 2:1 (2:0) | ||
| 2nd (2nd leg) | CF América | - | Deportivo Toluca | 1:1 (1:1) | ||
| 1st(1st leg): 20/10/2022 03:06 | 2nd (2nd leg): 23/10/2022 02:06 | Winner: Deportivo Toluca | ||||
| 1st(1st leg) | CF Pachuca | - | CF Monterrey | 5:2 (2:2) | ||
| 2nd (2nd leg) | CF Monterrey | - | CF Pachuca | 0:1 (0:0) | ||
| 1st(1st leg): 21/10/2022 03:06 | 2nd (2nd leg): 24/10/2022 02:06 | Winner: CF Pachuca | ||||
