 |
 |
|
|
| 23/10/2021 | 03:00 | Mazatlán FC | - | Gallos Blancos | 2:1 (0:1) | |
| 23:00 | Puebla FC | - | Club León | 0:1 (0:0) | ||
| 23:06 | CF Monterrey | - | Club Necaxa | 0:1 (0:0) | ||
| 24/10/2021 | 01:00 | CF América | - | UANL Tigres | 1:0 (0:0) | |
| 03:00 | Deportivo Guadalajara | - | Cruz Azul | 1:1 (0:1) | ||
| 18:00 | Pumas UNAM | - | Club Tijuana | 3:1 (1:0) | ||
| 25/10/2021 | 01:00 | Atlético San Luis | - | Atlas Guadalajara | 2:6 (0:4) | |
| 01:06 | Santos Laguna | - | Deportivo Toluca | 2:2 (1:0) | ||
| 03:00 | CF Pachuca | - | FC Juárez | 1:1 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 15 | 10 | 4 | 1 | 20:8 | 12 | 34 |
| 2 |
|
Atlas Guadalajara | 15 | 7 | 5 | 3 | 19:8 | 11 | 26 |
| 3 |
|
Club León | 15 | 7 | 4 | 4 | 17:14 | 3 | 25 |
| 4 |
|
Deportivo Toluca | 15 | 6 | 5 | 4 | 22:21 | 1 | 23 |
| 5 |
|
UANL Tigres | 15 | 5 | 7 | 3 | 21:13 | 8 | 22 |
| 6 |
|
Santos Laguna | 15 | 4 | 8 | 3 | 20:14 | 6 | 20 |
| 7 |
|
Cruz Azul | 15 | 4 | 8 | 3 | 16:12 | 4 | 20 |
| 8 |
|
CF Monterrey | 15 | 5 | 5 | 5 | 18:15 | 3 | 20 |
| 9 |
|
Mazatlán FC | 15 | 5 | 5 | 5 | 17:21 | -4 | 20 |
| 10 |
|
Deportivo Guadalajara | 15 | 4 | 7 | 4 | 11:11 | 0 | 19 |
| 11 |
|
Puebla FC | 15 | 4 | 6 | 5 | 13:16 | -3 | 18 |
| 12 |
|
Atlético San Luis | 15 | 4 | 6 | 5 | 18:22 | -4 | 18 |
| 13 |
|
CF Pachuca | 15 | 4 | 5 | 6 | 16:17 | -1 | 17 |
| 14 |
|
Club Necaxa | 15 | 5 | 2 | 8 | 14:18 | -4 | 17 |
| 15 |
|
Pumas UNAM | 15 | 4 | 5 | 6 | 12:19 | -7 | 17 |
| 16 |
|
FC Juárez | 15 | 4 | 4 | 7 | 14:20 | -6 | 16 |
| 17 |
|
Gallos Blancos | 15 | 3 | 6 | 6 | 9:14 | -5 | 15 |
| 18 |
|
Club Tijuana | 15 | 1 | 6 | 8 | 11:25 | -14 | 9 |
| Playoffs | |
| Playoffs |
