 |
 |
|
| 05/11/2021 | 03:00 | Atlas Guadalajara | - | Gallos Blancos | 2:0 (0:0) | |
| 06/11/2021 | 01:00 | Puebla FC | - | Deportivo Toluca | 1:0 (0:0) | |
| 03:00 | Mazatlán FC | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| 23:00 | Club León | - | Club Necaxa | 3:0 (1:0) | ||
| 07/11/2021 | 01:00 | CF América | - | CF Monterrey | 0:0 (0:0) | |
| 03:00 | UANL Tigres | - | FC Juárez | 3:0 (1:0) | ||
| 03:06 | Club Tijuana | - | CF Pachuca | 3:2 (1:1) | ||
| 23:00 | Pumas UNAM | - | Cruz Azul | 4:3 (1:3) | ||
| 08/11/2021 | 01:06 | Santos Laguna | - | Atlético San Luis | 0:0 (0:0) |
| » Tables | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 17 | 10 | 5 | 2 | 21:10 | 11 | 35 |
| 2 |
|
Atlas Guadalajara | 17 | 8 | 5 | 4 | 21:10 | 11 | 29 |
| 3 |
|
Club León | 17 | 8 | 5 | 4 | 20:14 | 6 | 29 |
| 4 |
|
UANL Tigres | 17 | 7 | 7 | 3 | 26:14 | 12 | 28 |
| 5 |
|
Santos Laguna | 17 | 5 | 9 | 3 | 23:16 | 7 | 24 |
| 6 |
|
Deportivo Toluca | 17 | 6 | 6 | 5 | 22:22 | 0 | 24 |
| 7 |
|
Puebla FC | 17 | 6 | 6 | 5 | 16:16 | 0 | 24 |
| 8 |
|
Cruz Azul | 17 | 5 | 8 | 4 | 21:17 | 4 | 23 |
| 9 |
|
CF Monterrey | 17 | 5 | 7 | 5 | 19:16 | 3 | 22 |
| 10 |
|
Deportivo Guadalajara | 17 | 5 | 7 | 5 | 13:13 | 0 | 22 |
| 11 |
|
Pumas UNAM | 17 | 5 | 6 | 6 | 17:23 | -6 | 21 |
| 12 |
|
Atlético San Luis | 17 | 4 | 8 | 5 | 19:23 | -4 | 20 |
| 13 |
|
Mazatlán FC | 17 | 5 | 5 | 7 | 18:24 | -6 | 20 |
| 14 |
|
Club Necaxa | 17 | 6 | 2 | 9 | 16:22 | -6 | 20 |
| 15 |
|
CF Pachuca | 17 | 4 | 6 | 7 | 19:21 | -2 | 18 |
| 16 |
|
FC Juárez | 17 | 4 | 4 | 9 | 14:25 | -11 | 16 |
| 17 |
|
Gallos Blancos | 17 | 3 | 6 | 8 | 11:19 | -8 | 15 |
| 18 |
|
Club Tijuana | 17 | 3 | 6 | 8 | 16:27 | -11 | 15 |
| Playoffs | |
| Playoffs |
