 |
 |
|
| 30/04/2021 | 03:00 | Atlético San Luis | - | CF Pachuca | 1:5 (1:2) | |
| 01/05/2021 | 01:30 | Club Necaxa | - | Atlas Guadalajara | 1:5 (1:2) | |
| 03:30 | FC Juárez | - | Deportivo Toluca | 1:0 (0:0) | ||
| 23:00 | Deportivo Guadalajara | - | UANL Tigres | 0:0 (0:0) | ||
| 23:00 | Club León | - | Gallos Blancos | 2:1 (1:0) | ||
| 02/05/2021 | 01:00 | Cruz Azul | - | Club Tijuana | 1:1 (1:0) | |
| 03:06 | CF Monterrey | - | Mazatlán FC | 1:0 (1:0) | ||
| 03/05/2021 | 01:06 | Santos Laguna | - | Puebla FC | 0:0 (0:0) | |
| 03:05 | Pumas UNAM | - | CF América | 0:1 (0:0) |
| » Tables | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cruz Azul | 17 | 13 | 2 | 2 | 26:11 | 15 | 41 |
| 2 |
|
CF América | 17 | 12 | 2 | 3 | 26:14 | 12 | 38 |
| 3 |
|
Puebla FC | 17 | 7 | 7 | 3 | 25:14 | 11 | 28 |
| 4 |
|
CF Monterrey | 17 | 8 | 4 | 5 | 22:13 | 9 | 28 |
| 5 |
|
Santos Laguna | 17 | 7 | 5 | 5 | 18:13 | 5 | 26 |
| 6 |
|
Club León | 17 | 8 | 2 | 7 | 25:23 | 2 | 26 |
| 7 |
|
Atlas Guadalajara | 17 | 7 | 4 | 6 | 20:15 | 5 | 25 |
| 8 |
|
CF Pachuca | 17 | 6 | 5 | 6 | 20:19 | 1 | 23 |
| 9 |
|
Deportivo Guadalajara | 17 | 5 | 8 | 4 | 21:21 | 0 | 23 |
| 10 |
|
UANL Tigres | 17 | 6 | 5 | 6 | 19:20 | -1 | 23 |
| 11 |
|
Deportivo Toluca | 17 | 6 | 4 | 7 | 26:24 | 2 | 22 |
| 12 |
|
Gallos Blancos | 17 | 6 | 3 | 8 | 19:25 | -6 | 21 |
| 13 |
|
Mazatlán FC | 17 | 6 | 3 | 8 | 19:26 | -7 | 21 |
| 14 |
|
Club Tijuana | 17 | 5 | 5 | 7 | 19:21 | -2 | 20 |
| 15 |
|
Pumas UNAM | 17 | 4 | 6 | 7 | 10:12 | -2 | 18 |
| 16 |
|
FC Juárez | 17 | 4 | 3 | 10 | 13:29 | -16 | 15 |
| 17 |
|
Atlético San Luis | 17 | 3 | 3 | 11 | 20:33 | -13 | 12 |
| 18 |
|
Club Necaxa | 17 | 2 | 5 | 10 | 14:29 | -15 | 11 |
| Playoffs | |
| Playoffs |
