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| 1st(1st leg) | Deportivo Guadalajara | - | Club León | 1:1 (0:1) | ||
| 2nd (2nd leg) | Club León | - | Deportivo Guadalajara | 1:0 (1:0) | ||
| 1st(1st leg): 03/12/2020 03:05 | 2nd (2nd leg): 06/12/2020 03:00 | Winner: Club León | ||||
| 1st(1st leg) | Cruz Azul | - | Pumas UNAM | 4:0 (3:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | Cruz Azul | 4:0 (3:0) | ||
| 1st(1st leg): 04/12/2020 03:00 | 2nd (2nd leg): 07/12/2020 00:30 | |||||
