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| 1st(1st leg) | CF Pachuca | - | UANL Tigres | 1:1 (1:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | CF Pachuca | 1:1 (0:0) | ||
| 1st(1st leg): 09/05/2019 01:00 | 2nd (2nd leg): 12/05/2019 01:00 | |||||
| 1st(1st leg) | Club Tijuana | - | Club León | 1:3 (0:1) | ||
| 2nd (2nd leg) | Club León | - | Club Tijuana | 2:1 (2:1) | ||
| 1st(1st leg): 09/05/2019 03:06 | 2nd (2nd leg): 12/05/2019 03:06 | Winner: Club León | ||||
| 1st(1st leg) | Club Necaxa | - | CF Monterrey | 1:0 (1:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Club Necaxa | 1:0 (1:0) | ||
| 1st(1st leg): 10/05/2019 01:00 | 2nd (2nd leg): 13/05/2019 02:00 | |||||
| 1st(1st leg) | CF América | - | Cruz Azul | 3:1 (2:1) | ||
| 2nd (2nd leg) | Cruz Azul | - | CF América | 1:0 (0:0) | ||
| 1st(1st leg): 10/05/2019 03:05 | 2nd (2nd leg): 13/05/2019 00:10 | Winner: CF América | ||||
