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| 1st(1st leg) | Deportivo Toluca | - | Monarcas Morelia | 2:1 (0:0) | ||
| 2nd (2nd leg) | Monarcas Morelia | - | Deportivo Toluca | 2:1 (2:1) | ||
| 1st(1st leg): 23/11/2017 01:30 | 2nd (2nd leg): 26/11/2017 03:00 | |||||
| 1st(1st leg) | Club León | - | UANL Tigres | 1:1 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Club León | 1:1 (1:1) | ||
| 1st(1st leg): 23/11/2017 03:36 | 2nd (2nd leg): 26/11/2017 01:00 | |||||
| 1st(1st leg) | Cruz Azul | - | CF América | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF América | - | Cruz Azul | 0:0 (0:0) | ||
| 1st(1st leg): 24/11/2017 01:30 | 2nd (2nd leg): 27/11/2017 02:00 | |||||
| 1st(1st leg) | Atlas Guadalajara | - | CF Monterrey | 1:2 (1:2) | ||
| 2nd (2nd leg) | CF Monterrey | - | Atlas Guadalajara | 4:1 (4:1) | ||
| 1st(1st leg): 24/11/2017 03:30 | 2nd (2nd leg): 27/11/2017 00:00 | Winner: CF Monterrey | ||||
