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| 1st(1st leg) | CF América | - | Santos Laguna | 1:2 (1:1) | ||
| 2nd (2nd leg) | Santos Laguna | - | CF América | 3:3 (1:0) | ||
| 1st(1st leg): 26/11/2010 01:00 | 2nd (2nd leg): 29/11/2010 00:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | Pumas UNAM | - | CF Monterrey | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Pumas UNAM | 2:0 (0:0) | ||
| 1st(1st leg): 26/11/2010 03:00 | 2nd (2nd leg): 29/11/2010 02:00 | Winner: CF Monterrey | ||||
