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| 1st(1st leg) | Cruz Azul | - | Atlante | 0:1 (0:1) | ||
| 2nd (2nd leg) | Atlante | - | Cruz Azul | 2:1 (1:0) | ||
| 1st(1st leg): 22/11/2007 01:00 | 2nd (2nd leg): 25/11/2007 03:00 | Winner: Atlante | ||||
| 1st(1st leg) | Club San Luis | - | Deportivo Guadalajara | 1:1 (0:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Club San Luis | 1:0 (0:0) | ||
| 1st(1st leg): 22/11/2007 03:00 | 2nd (2nd leg): 25/11/2007 01:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Monarcas Morelia | - | Santos Laguna | 0:2 (0:1) | ||
| 2nd (2nd leg) | Santos Laguna | - | Monarcas Morelia | 3:2 (1:0) | ||
| 1st(1st leg): 23/11/2007 01:00 | 2nd (2nd leg): 25/11/2007 22:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | Pumas UNAM | - | Deportivo Toluca | 2:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Pumas UNAM | 1:1 (1:0) | ||
| 1st(1st leg): 23/11/2007 03:00 | 2nd (2nd leg): 25/11/2007 18:00 | Winner: Pumas UNAM | ||||
