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| 1st(1st leg) | Club Irapuato | - | Cruz Azul Hidalgo | 2:0 (0:0) | ||
| 2nd (2nd leg) | Cruz Azul Hidalgo | - | Club Irapuato | 1:1 (1:0) | ||
| 1st(1st leg): 10/05/2021 01:30 | 2nd (2nd leg): 16/05/2021 18:00 | Winner: Club Irapuato | ||||
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| 1st(1st leg) | Club Irapuato | - | Cruz Azul Hidalgo | 2:0 (0:0) | ||
| 2nd (2nd leg) | Cruz Azul Hidalgo | - | Club Irapuato | 1:1 (1:0) | ||
| 1st(1st leg): 10/05/2021 01:30 | 2nd (2nd leg): 16/05/2021 18:00 | Winner: Club Irapuato | ||||
