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| 1st(1st leg) | Tepatitlán | - | Loros UCOL | 0:2 | ||
| 2nd (2nd leg) | Loros UCOL | - | Tepatitlán | 1:1 | ||
| 1st(1st leg): 25/04/2018 23:00 | 2nd (2nd leg): 28/04/2018 22:00 | Winner: Loros UCOL | ||||
| 1st(1st leg) | Inter Playa | - | Club Irapuato | 2:2 | ||
| 2nd (2nd leg) | Club Irapuato | - | Inter Playa | 3:0 | ||
| 1st(1st leg): 26/04/2018 01:00 | 2nd (2nd leg): 29/04/2018 01:00 | Winner: Club Irapuato | ||||
| 1st(1st leg) | Alacranes de Durango | - | Reboceros de La Piedad | 0:1 | ||
| 2nd (2nd leg) | Reboceros de La Piedad | - | Alacranes de Durango | 1:0 | ||
| 1st(1st leg): 26/04/2018 02:00 | 2nd (2nd leg): 29/04/2018 02:00 | Winner: Reboceros de La Piedad | ||||
| 1st(1st leg) | Atlético Reynosa | - | Tuxtla FC | 1:1 | ||
| 2nd (2nd leg) | Tuxtla FC | - | Atlético Reynosa | 1:2 | ||
| 1st(1st leg): 27/04/2018 01:30 | 2nd (2nd leg): 29/04/2018 22:00 | Winner: Atlético Reynosa | ||||
