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| 1st(1st leg) | Club Calor | - | Atlético Pachuca | 1:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Pachuca | - | Club Calor | 1:0 (0:0) | ||
| 1st(1st leg): 12/04/2025 19:00 | 2nd (2nd leg): 19/04/2025 23:00 | |||||
| 1st(1st leg) | CDM FC | - | Santiago FC | 0:4 (0:3) | ||
| 2nd (2nd leg) | Santiago FC | - | CDM FC | 0:0 (0:0) | ||
| 1st(1st leg): 12/04/2025 23:00 | 2nd (2nd leg): 20/04/2025 01:00 | Winner: Santiago FC | ||||
| 1st(1st leg) | Cordobés FC | - | CD Ayense | 1:2 (0:2) | ||
| 2nd (2nd leg) | CD Ayense | - | Cordobés FC | 4:0 (2:0) | ||
| 1st(1st leg): 12/04/2025 23:00 | 2nd (2nd leg): 20/04/2025 01:00 | Winner: CD Ayense | ||||
| 1st(1st leg) | Cañoneros FC | - | Artesanos Metepec | 1:1 (0:1) | ||
| 2nd (2nd leg) | Artesanos Metepec | - | Cañoneros FC | 4:1 (2:0) | ||
| 1st(1st leg): 12/04/2025 23:30 | 2nd (2nd leg): 19/04/2025 23:00 | Winner: Artesanos Metepec | ||||
