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| 1st(1st leg) | Sporting Canamy | - | Tampico Madero | 2:3 (0:2) | ||
| 2nd (2nd leg) | Tampico Madero | - | Sporting Canamy | 3:1 (2:1) | ||
| 1st(1st leg): 26/10/2022 22:00 | 2nd (2nd leg): 30/10/2022 01:00 | Winner: Tampico Madero | ||||
| 1st(1st leg) | Aguacateros CDU | - | Tuzos de la UAZ | 1:1 (1:1) | ||
| 2nd (2nd leg) | Tuzos de la UAZ | - | Aguacateros CDU | 3:0 (1:0) | ||
| 1st(1st leg): 26/10/2022 22:00 | 2nd (2nd leg): 29/10/2022 22:00 | Winner: Tuzos de la UAZ | ||||
| 1st(1st leg) | Reboceros de La Piedad | - | Cafetaleros de Chiapas | 0:1 (0:0) | ||
| 2nd (2nd leg) | Cafetaleros de Chiapas | - | Reboceros de La Piedad | 3:1 (2:0) | ||
| 1st(1st leg): 27/10/2022 02:00 | 2nd (2nd leg): 30/10/2022 01:00 | Winner: Cafetaleros de Chiapas | ||||
| 1st(1st leg) | Chihuahua FC | - | Los Cabos United | 2:0 (0:0) | ||
| 2nd (2nd leg) | Los Cabos United | - | Chihuahua FC | 2:1 (0:0) | ||
| 1st(1st leg): 27/10/2022 03:00 | 2nd (2nd leg): 30/10/2022 02:00 | Winner: Chihuahua FC | ||||
