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| 1st(1st leg) | Tritones Vallarta | - | Mazorqueros | 1:2 (1:1) | ||
| 2nd (2nd leg) | Mazorqueros | - | Tritones Vallarta | 5:4 (0:1, 0:1) pso | ||
| 1st(1st leg): 27/04/2022 22:30 | 2nd (2nd leg): 30/04/2022 23:30 | Winner: Mazorqueros | ||||
| 1st(1st leg) | Cafetaleros de Chiapas | - | Inter Playa | 0:0 (0:0) | ||
| 2nd (2nd leg) | Inter Playa | - | Cafetaleros de Chiapas | 0:1 (0:0) | ||
| 1st(1st leg): 28/04/2022 02:00 | 2nd (2nd leg): 30/04/2022 22:00 | Winner: Cafetaleros de Chiapas | ||||
