 |
 |
|
|
| 1st(1st leg) | Venados FC | - | Leones Negros | 2:0 (1:0) | ||
| 2nd (2nd leg) | Leones Negros | - | Venados FC | 3:0 (2:0) | ||
| 1st(1st leg): 26/10/2022 01:00 | 2nd (2nd leg): 29/10/2022 01:00 | Winner: Leones Negros | ||||
| 1st(1st leg) | Atlético Morelia | - | Cimarrones de Sonora | 2:0 (1:0) | ||
| 2nd (2nd leg) | Cimarrones de Sonora | - | Atlético Morelia | 3:1 (3:1) | ||
| 1st(1st leg): 26/10/2022 03:05 | 2nd (2nd leg): 29/10/2022 03:15 | Winner: Atlético Morelia | ||||
| 1st(1st leg) | Alacranes de Durango | - | Club Celaya | 0:1 (0:0) | ||
| 2nd (2nd leg) | Club Celaya | - | Alacranes de Durango | 1:0 (0:0) | ||
| 1st(1st leg): 26/10/2022 23:00 | 2nd (2nd leg): 30/10/2022 00:00 | Winner: Club Celaya | ||||
| 1st(1st leg) | Mineros de Zacatecas | - | Atlante | 1:2 (1:2) | ||
| 2nd (2nd leg) | Atlante | - | Mineros de Zacatecas | 2:1 (2:1) | ||
| 1st(1st leg): 27/10/2022 01:05 | 2nd (2nd leg): 30/10/2022 01:00 | Winner: Atlante | ||||
