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| 1st(1st leg) | Atlante | - | Atlético Morelia | 0:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Morelia | - | Atlante | 1:1 (1:1) | ||
| 1st(1st leg): 04/05/2021 22:00 | 2nd (2nd leg): 08/05/2021 03:00 | Winner: Atlético Morelia | ||||
| 1st(1st leg) | Tepatitlán | - | Mineros de Zacatecas | 3:0 (0:0) | ||
| 2nd (2nd leg) | Mineros de Zacatecas | - | Tepatitlán | 1:1 (1:0) | ||
| 1st(1st leg): 05/05/2021 23:00 | 2nd (2nd leg): 08/05/2021 23:00 | Winner: Tepatitlán | ||||
