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| 1st(1st leg) | Coyotes de Tlaxcala | - | Atlético Morelia | 0:2 (0:2) | ||
| 2nd (2nd leg) | Atlético Morelia | - | Coyotes de Tlaxcala | 3:0 (3:0) | ||
| 1st(1st leg): 02/12/2020 23:00 | 2nd (2nd leg): 05/12/2020 23:00 | Winner: Atlético Morelia | ||||
| 1st(1st leg) | Mineros de Zacatecas | - | TM Fútbol Club | 2:1 (1:1) | ||
| 2nd (2nd leg) | TM Fútbol Club | - | Mineros de Zacatecas | 3:0 (3:0) | ||
| 1st(1st leg): 03/12/2020 01:00 | 2nd (2nd leg): 06/12/2020 01:00 | Winner: TM Fútbol Club | ||||
| 1st(1st leg) | Pumas Tabasco | - | Atlante | 1:1 (0:1) | ||
| 2nd (2nd leg) | Atlante | - | Pumas Tabasco | 0:0 (0:0) | ||
| 1st(1st leg): 04/12/2020 01:00 | 2nd (2nd leg): 07/12/2020 03:00 | Winner: Atlante | ||||
