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| 1st(1st leg) | Deportivo Toluca | - | CF América | 2:2 (2:1) | ||
| 2nd (2nd leg) | CF América | - | Deportivo Toluca | 3:1 (3:1) | ||
| 1st(1st leg): 22/11/2018 00:00 | 2nd (2nd leg): 24/11/2018 21:00 | Winner: CF América | ||||
| 1st(1st leg) | CF Monterrey | - | Deportivo Guadalajara | 1:1 (1:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Monterrey | 0:0 (0:0) | ||
| 1st(1st leg): 23/11/2018 01:00 | 2nd (2nd leg): 26/11/2018 01:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Atlas Guadalajara | - | UANL Tigres | 1:2 (0:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | Atlas Guadalajara | 0:0 (0:0) | ||
| 1st(1st leg): 23/11/2018 17:00 | 2nd (2nd leg): 27/11/2018 02:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Pumas UNAM | - | CF Pachuca | 0:1 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Pumas UNAM | 5:1 (1:1) | ||
| 1st(1st leg): 23/11/2018 21:00 | 2nd (2nd leg): 27/11/2018 00:00 | Winner: CF Pachuca | ||||
