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| 1st(1st leg) | Atlas Guadalajara | - | CF Pachuca | 1:1 (1:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Atlas Guadalajara | 4:1 (1:0) | ||
| 1st(1st leg): 24/04/2025 02:00 | 2nd (2nd leg): 27/04/2025 04:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | FC Juárez | - | CF América | 2:2 (0:0) | ||
| 2nd (2nd leg) | CF América | - | FC Juárez | 5:0 (4:0) | ||
| 1st(1st leg): 24/04/2025 04:00 | 2nd (2nd leg): 27/04/2025 02:00 | Winner: CF América | ||||
| 1st(1st leg) | Deportivo Guadalajara | - | Pumas UNAM | 2:0 (0:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| 1st(1st leg): 25/04/2025 02:00 | 2nd (2nd leg): 27/04/2025 19:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | UANL Tigres | - | CF Monterrey | 1:1 (1:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | UANL Tigres | 1:1 (0:1) | ||
| 1st(1st leg): 26/04/2025 03:00 | 2nd (2nd leg): 29/04/2025 03:00 | |||||
