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| 1st(1st leg) | CF Pachuca | - | Deportivo Guadalajara | 3:3 (2:2) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Pachuca | 1:3 (0:1) | ||
| 1st(1st leg): 19/05/2023 01:00 | 2nd (2nd leg): 22/05/2023 00:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Atlas Guadalajara | - | UANL Tigres | 0:5 (0:3) | ||
| 2nd (2nd leg) | UANL Tigres | - | Atlas Guadalajara | 2:0 (0:0) | ||
| 1st(1st leg): 20/05/2023 01:00 | 2nd (2nd leg): 23/05/2023 02:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | FC Juárez | - | CF América | 1:3 (0:2) | ||
| 2nd (2nd leg) | CF América | - | FC Juárez | 5:1 (2:0) | ||
| 1st(1st leg): 20/05/2023 03:00 | 2nd (2nd leg): 23/05/2023 00:00 | Winner: CF América | ||||
| 1st(1st leg) | Club Tijuana | - | CF Monterrey | 2:0 (2:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Club Tijuana | 6:1 (1:1) | ||
| 1st(1st leg): 20/05/2023 05:00 | 2nd (2nd leg): 23/05/2023 04:00 | Winner: CF Monterrey | ||||
