 |
 |
|
|
| 22/04/2022 | 23:00 | Gallos Blancos | - | Puebla FC | 1:0 (0:0) | |
| 23:00 | Club Necaxa | - | Cruz Azul | 1:2 (1:1) | ||
| 23/04/2022 | 18:00 | Atlas Guadalajara | - | Deportivo Guadalajara | 0:1 (0:0) | |
| 18:00 | Pumas UNAM | - | Atlético San Luis | 2:1 (0:0) | ||
| 25/04/2022 | 01:00 | Mazatlán FC | - | Club Tijuana | 2:1 (1:0) | |
| 26/04/2022 | 01:00 | CF América | - | CF Pachuca | 4:0 (1:0) | |
| 01:00 | Club León | - | Deportivo Toluca | 2:2 (0:1) | ||
| 01:00 | Santos Laguna | - | FC Juárez | 3:1 (2:1) | ||
| 03:00 | CF Monterrey | - | UANL Tigres | 0:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Monterrey | 16 | 14 | 1 | 1 | 51:12 | 39 | 43 |
| 2 |
|
Deportivo Guadalajara | 16 | 12 | 4 | 0 | 26:6 | 20 | 40 |
| 3 |
|
UANL Tigres | 16 | 11 | 5 | 0 | 42:10 | 32 | 38 |
| 4 |
|
CF América | 16 | 11 | 3 | 2 | 40:13 | 27 | 36 |
| 5 |
|
CF Pachuca | 16 | 9 | 2 | 5 | 27:21 | 6 | 29 |
| 6 |
|
Atlas Guadalajara | 16 | 6 | 6 | 4 | 25:24 | 1 | 24 |
| 7 |
|
Deportivo Toluca | 16 | 5 | 5 | 6 | 27:29 | -2 | 20 |
| 8 |
|
Pumas UNAM | 16 | 5 | 4 | 7 | 15:15 | 0 | 19 |
| 9 |
|
Club Tijuana | 16 | 3 | 9 | 4 | 21:27 | -6 | 18 |
| 10 |
|
Cruz Azul | 16 | 5 | 3 | 8 | 19:29 | -10 | 18 |
| 11 |
|
Gallos Blancos | 16 | 5 | 3 | 8 | 15:26 | -11 | 18 |
| 12 |
|
Atlético San Luis | 16 | 4 | 5 | 7 | 20:28 | -8 | 17 |
| 13 |
|
Santos Laguna | 16 | 4 | 2 | 10 | 16:29 | -13 | 14 |
| 14 |
|
Club Necaxa | 16 | 3 | 5 | 8 | 16:30 | -14 | 14 |
| 15 |
|
Mazatlán FC | 16 | 3 | 4 | 9 | 11:29 | -18 | 13 |
| 16 |
|
Club León | 16 | 3 | 4 | 9 | 17:38 | -21 | 13 |
| 17 |
|
Puebla FC | 16 | 3 | 3 | 10 | 10:22 | -12 | 12 |
| 18 |
|
FC Juárez | 16 | 3 | 2 | 11 | 16:26 | -10 | 11 |
| Playoffs |
