 |
 |
|
|
| 09/10/2021 | 02:00 | Mazatlán FC | - | Gallos Blancos | 1:0 (0:0) | |
| 18:00 | Atlas Guadalajara | - | Club Necaxa | 1:0 (0:0) | ||
| 18:00 | Cruz Azul | - | Club León | 0:0 (0:0) | ||
| 22:00 | Deportivo Toluca | - | Santos Laguna | 1:0 (1:0) | ||
| 10/10/2021 | 01:30 | UANL Tigres | - | CF Monterrey | 2:1 (1:1) | |
| 23:00 | Atlético San Luis | - | FC Juárez | 4:0 (1:0) | ||
| 12/10/2021 | 01:00 | CF Pachuca | - | Pumas UNAM | 1:1 (1:1) | |
| 03:00 | Deportivo Guadalajara | - | CF América | 2:1 (0:0) | ||
| 03:00 | Club Tijuana | - | Puebla FC | 2:0 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 12 | 12 | 0 | 0 | 43:4 | 39 | 36 |
| 2 |
|
CF Monterrey | 12 | 9 | 2 | 1 | 26:7 | 19 | 29 |
| 3 |
|
Deportivo Guadalajara | 12 | 9 | 1 | 2 | 28:11 | 17 | 28 |
| 4 |
|
Santos Laguna | 12 | 7 | 3 | 2 | 30:15 | 15 | 24 |
| 5 |
|
CF América | 12 | 7 | 3 | 2 | 23:11 | 12 | 24 |
| 6 |
|
Atlas Guadalajara | 12 | 6 | 3 | 3 | 17:13 | 4 | 21 |
| 7 |
|
Club Tijuana | 12 | 5 | 3 | 4 | 15:13 | 2 | 18 |
| 8 |
|
Pumas UNAM | 12 | 3 | 6 | 3 | 12:11 | 1 | 15 |
| 9 |
|
Cruz Azul | 12 | 4 | 3 | 5 | 9:18 | -9 | 15 |
| 10 |
|
Club Necaxa | 12 | 4 | 2 | 6 | 10:23 | -13 | 14 |
| 11 |
|
Deportivo Toluca | 12 | 3 | 3 | 6 | 11:18 | -7 | 12 |
| 12 |
|
CF Pachuca | 12 | 2 | 5 | 5 | 15:20 | -5 | 11 |
| 13 |
|
Gallos Blancos | 12 | 2 | 4 | 6 | 12:16 | -4 | 10 |
| 14 |
|
Club León | 12 | 2 | 4 | 6 | 13:22 | -9 | 10 |
| 15 |
|
Puebla FC | 12 | 3 | 1 | 8 | 13:23 | -10 | 10 |
| 16 |
|
Atlético San Luis | 12 | 2 | 4 | 6 | 11:24 | -13 | 10 |
| 17 |
|
Mazatlán FC | 12 | 1 | 3 | 8 | 6:25 | -19 | 6 |
| 18 |
|
FC Juárez | 12 | 1 | 2 | 9 | 6:26 | -20 | 5 |
| Playoffs |
