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| 12/01/2019 | 14:00 | Lazio Roma | - | Novara Calcio | 4:1 (4:0) | |
| 17:00 | Sampdoria | - | AC Milan | 0:2 (0:0, 0:0) aet | ||
| 19:45 | Bologna FC | - | Juventus | 0:2 (0:1) | ||
| 13/01/2019 | 14:00 | Torino FC | - | ACF Fiorentina | 0:2 (0:0) | |
| 17:00 | Inter | - | Benevento Calcio | 6:2 (3:0) | ||
| 19:45 | SSC Napoli | - | Sassuolo Calcio | 2:0 (1:0) | ||
| 14/01/2019 | 16:30 | Cagliari Calcio | - | Atalanta | 0:2 (0:0) | |
| 20:00 | AS Roma | - | Virtus Entella | 4:0 (2:0) |
