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| 1st(1st leg) | Marathón | - | Real España | 0:2 (0:1) | ||
| 2nd (2nd leg) | Real España | - | Marathón | 1:1 (1:0) | ||
| 1st(1st leg): 12/05/2022 02:06 | 2nd (2nd leg): 15/05/2022 02:00 | Winner: Real España | ||||
| 1st(1st leg) | Motagua | - | Olimpia | 1:1 (1:1) | ||
| 2nd (2nd leg) | Olimpia | - | Motagua | 0:1 (0:1) | ||
| 1st(1st leg): 13/05/2022 02:00 | 2nd (2nd leg): 16/05/2022 00:00 | Winner: Motagua | ||||
