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| 1st(1st leg) | Marathón | - | Olimpia | 1:0 (1:0) | ||
| 2nd (2nd leg) | Olimpia | - | Marathón | 3:0 (1:0) | ||
| 1st(1st leg): 19/11/2021 01:00 | 2nd (2nd leg): 21/11/2021 22:00 | Winner: Olimpia | ||||
| 1st(1st leg) | Lobos UPNFM | - | Motagua | 1:2 (0:0) | ||
| 2nd (2nd leg) | Motagua | - | Lobos UPNFM | 3:1 (2:1) | ||
| 1st(1st leg): 19/11/2021 01:05 | 2nd (2nd leg): 21/11/2021 01:10 | Winner: Motagua | ||||
