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| 1st(1st leg) | Vida | - | Olimpia | 0:0 (0:0) | ||
| 2nd (2nd leg) | Olimpia | - | Vida | 3:0 (2:0) | ||
| 1st(1st leg): 30/12/2020 23:15 | 2nd (2nd leg): 03/01/2021 22:00 | Winner: Olimpia | ||||
| 1st(1st leg) | Motagua | - | Marathón | 2:0 (1:0) | ||
| 2nd (2nd leg) | Marathón | - | Motagua | 1:2 (1:2) | ||
| 1st(1st leg): 31/12/2020 01:00 | 2nd (2nd leg): 03/01/2021 20:00 | Winner: Motagua | ||||
