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| 1st(1st leg) | Lobos UPNFM | - | Olimpia | 1:3 | ||
| 2nd (2nd leg) | Olimpia | - | Lobos UPNFM | 4:1 | ||
| 1st(1st leg): 11/05/2019 22:00 | 2nd (2nd leg): 19/05/2019 23:00 | Winner: Olimpia | ||||
| 1st(1st leg) | Motagua | - | Marathón | 2:0 | ||
| 2nd (2nd leg) | Marathón | - | Motagua | 2:2 | ||
| 1st(1st leg): 12/05/2019 23:00 | 2nd (2nd leg): 18/05/2019 22:00 | Winner: Motagua | ||||
