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| 1st(1st leg) | Honduras Progreso | - | Real España | 1:1 (1:0) | ||
| 2nd (2nd leg) | Real España | - | Honduras Progreso | 0:0 (0:0) | ||
| 1st(1st leg): 19/04/2018 02:15 | 2nd (2nd leg): 22/04/2018 02:00 | Winner: Real España | ||||
| 1st(1st leg) | Platense | - | Olimpia | 0:0 (0:0) | ||
| 2nd (2nd leg) | Olimpia | - | Platense | 2:1 (2:0) | ||
| 1st(1st leg): 20/04/2018 02:15 | 2nd (2nd leg): 22/04/2018 23:00 | Winner: Olimpia | ||||
