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| 1st(1st leg) | Deportivo Guastatoya | - | Deportivo Xinabajul | 2:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Xinabajul | - | Deportivo Guastatoya | 1:0 (0:0) | ||
| 1st(1st leg): 10/05/2023 18:00 | 2nd (2nd leg): 14/05/2023 01:00 | Winner: Deportivo Guastatoya | ||||
| 1st(1st leg) | Deportivo Mixco | - | Xelaju MC | 0:1 (0:1) | ||
| 2nd (2nd leg) | Xelaju MC | - | Deportivo Mixco | 1:1 (1:1) | ||
| 1st(1st leg): 10/05/2023 23:00 | 2nd (2nd leg): 14/05/2023 03:00 | Winner: Xelaju MC | ||||
| 1st(1st leg) | Achuapa | - | Comunicaciones | 2:0 (2:0) | ||
| 2nd (2nd leg) | Comunicaciones | - | Achuapa | 4:1 (1:0, 2:0) aet | ||
| 1st(1st leg): 11/05/2023 22:30 | 2nd (2nd leg): 15/05/2023 01:00 | Winner: Comunicaciones | ||||
| 1st(1st leg) | Antigua GFC | - | CSD Municipal | 2:1 (1:1) | ||
| 2nd (2nd leg) | CSD Municipal | - | Antigua GFC | 1:3 (0:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 12/05/2023 02:00 | 2nd (2nd leg): 14/05/2023 22:00 | Winner: Antigua GFC | ||||
