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| 1st(1st leg) | Deportivo Malacateco | - | Antigua GFC | 2:0 (1:0) | ||
| 2nd (2nd leg) | Antigua GFC | - | Deportivo Malacateco | 1:1 (1:0) | ||
| 1st(1st leg): 22/12/2021 17:00 | 2nd (2nd leg): 26/12/2021 00:00 | Winner: Deportivo Malacateco | ||||
| 1st(1st leg) | CSD Municipal | - | Comunicaciones | 0:0 (0:0) | ||
| 2nd (2nd leg) | Comunicaciones | - | CSD Municipal | 0:0 (0:0) | ||
| 1st(1st leg): 23/12/2021 21:00 | 2nd (2nd leg): 27/12/2021 02:00 | |||||
