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| 1st(1st leg) | Sierra Leone | - | Gambia | 0:2 (0:0) | ||
| 2nd (2nd leg) | Gambia | - | Sierra Leone | 1:1 (1:0) | ||
| 1st(1st leg): 18/10/2021 17:00 | 2nd (2nd leg): 25/10/2021 17:30 | Winner: Gambia | ||||
| 1st(1st leg) | Uganda | - | Ethiopia | 2:0 (1:0) | ||
| 2nd (2nd leg) | Ethiopia | - | Uganda | 1:2 (2:0, 2:0) pso | ||
| 1st(1st leg): 20/10/2021 14:00 | 2nd (2nd leg): 26/10/2021 14:00 | Winner: Uganda | ||||
| 1st(1st leg) | Kenya | - | South Sudan | 8:0 (4:0) | ||
| 2nd (2nd leg) | South Sudan | - | Kenya | 1:7 (0:2) | ||
| 1st(1st leg): 20/10/2021 14:00 | 2nd (2nd leg): 23/10/2021 14:00 | Winner: Kenya | ||||
| 1st(1st leg) | Eritrea | - | Burundi | 0:5 | ||
| 2nd (2nd leg) | Burundi | - | Eritrea | 1:0 (1:0) | ||
| 1st(1st leg): 20/10/2021 14:00 | 2nd (2nd leg): 26/10/2021 14:00 | Winner: Burundi | ||||
| 1st(1st leg) | Malawi | - | Zambia | 1:1 (0:1) | ||
| 2nd (2nd leg) | Zambia | - | Malawi | 3:2 (2:1) | ||
| 1st(1st leg): 20/10/2021 14:00 | 2nd (2nd leg): 26/10/2021 14:00 | Winner: Zambia | ||||
| 1st(1st leg) | Tanzania | - | Namibia | 1:2 (1:1) | ||
| 2nd (2nd leg) | Namibia | - | Tanzania | 3:2 (3:1) | ||
| 1st(1st leg): 20/10/2021 14:00 | 2nd (2nd leg): 23/10/2021 14:30 | Winner: Namibia | ||||
| 1st(1st leg) | Zimbabwe | - | Eswatini | 3:1 (3:1) | ||
| 2nd (2nd leg) | Eswatini | - | Zimbabwe | 0:3 (0:1) | ||
| 1st(1st leg): 20/10/2021 14:00 | 2nd (2nd leg): 26/10/2021 14:00 | Winner: Zimbabwe | ||||
| 1st(1st leg) | Mozambique | - | South Africa | 0:7 (0:3) | ||
| 2nd (2nd leg) | South Africa | - | Mozambique | 6:0 (3:0) | ||
| 1st(1st leg): 20/10/2021 14:00 | 2nd (2nd leg): 26/10/2021 14:00 | Winner: South Africa | ||||
| 1st(1st leg) | Central Afr. Republic | - | Cameroon | 0:1 (0:0) | ||
| 2nd (2nd leg) | Cameroon | - | Central Afr. Republic | 2:0 (0:0) | ||
| 1st(1st leg): 20/10/2021 14:00 | 2nd (2nd leg): 24/10/2021 15:30 | Winner: Cameroon | ||||
| 1st(1st leg) | Egypt | - | Tunisia | 2:6 (1:2) | ||
| 2nd (2nd leg) | Tunisia | - | Egypt | 1:0 (0:0) | ||
| 1st(1st leg): 20/10/2021 15:00 | 2nd (2nd leg): 26/10/2021 15:00 | Winner: Tunisia | ||||
| 1st(1st leg) | Congo | - | Gabon | 2:1 (2:0) | ||
| 2nd (2nd leg) | Gabon | - | Congo | 1:0 (0:0) | ||
| 1st(1st leg): 20/10/2021 15:30 | 2nd (2nd leg): 26/10/2021 15:30 | Winner: Gabon | ||||
| 1st(1st leg) | Nigeria | - | Ghana | 2:0 (2:0) | ||
| 2nd (2nd leg) | Ghana | - | Nigeria | 1:0 (0:0) | ||
| 1st(1st leg): 20/10/2021 16:00 | 2nd (2nd leg): 24/10/2021 17:00 | Winner: Nigeria | ||||
| 1st(1st leg) | Niger | - | Ivory Coast | 0:9 (0:5) | ||
| 2nd (2nd leg) | Ivory Coast | - | Niger | 11:0 (5:0) | ||
| 1st(1st leg): 20/10/2021 16:30 | 2nd (2nd leg): 25/10/2021 16:30 | Winner: Ivory Coast | ||||
| 1st(1st leg) | Djibouti | - | Rwanda | 3:0 dec. | ||
| 2nd (2nd leg) | Rwanda | - | Djibouti | 0:3 dec. | ||
| 1st(1st leg): 20/10/2021 17:00 | 2nd (2nd leg): 26/10/2021 15:00 | Winner: Djibouti | ||||
| 1st(1st leg) | Angola | - | Botswana | 1:5 (1:2) | ||
| 2nd (2nd leg) | Botswana | - | Angola | 2:0 (2:0) | ||
| 1st(1st leg): 20/10/2021 17:00 | 2nd (2nd leg): 26/10/2021 17:15 | Winner: Botswana | ||||
| 1st(1st leg) | Liberia | - | Senegal | 1:2 (0:1) | ||
| 2nd (2nd leg) | Senegal | - | Liberia | 6:0 (4:0) | ||
| 1st(1st leg): 20/10/2021 17:00 | 2nd (2nd leg): 26/10/2021 18:00 | Winner: Senegal | ||||
| 1st(1st leg) | Burkina Faso | - | Benin | 2:1 (0:1) | ||
| 2nd (2nd leg) | Benin | - | Burkina Faso | 1:3 (0:1) | ||
| 1st(1st leg): 20/10/2021 17:00 | 2nd (2nd leg): 24/10/2021 17:00 | Winner: Burkina Faso | ||||
| 1st(1st leg) | Mali | - | Guinea | 2:2 (2:1) | ||
| 2nd (2nd leg) | Guinea | - | Mali | 0:2 (0:0) | ||
| 1st(1st leg): 20/10/2021 17:30 | 2nd (2nd leg): 25/10/2021 17:00 | Winner: Mali | ||||
| 1st(1st leg) | Guinea-Bissau | - | Mauritania | 1:0 (0:0) | ||
| 2nd (2nd leg) | Mauritania | - | Guinea-Bissau | 0:1 (0:0) | ||
| 1st(1st leg): 20/10/2021 17:30 | 2nd (2nd leg): 26/10/2021 17:00 | Winner: Guinea-Bissau | ||||
| 1st(1st leg) | Algeria | - | Sudan | 14:0 (9:0) | ||
| 2nd (2nd leg) | Sudan | - | Algeria | dnp | ||
| 1st(1st leg): 20/10/2021 18:00 | 2nd (2nd leg): 26/10/2021 | Winner: Algeria | ||||
| 1st(1st leg) | Equatorial Guinea | - | Congo DR | 3:0 dec. | ||
| 2nd (2nd leg) | Congo DR | - | Equatorial Guinea | 0:3 dec. | ||
| 1st(1st leg): 20/10/2021 18:00 | 2nd (2nd leg): 24/10/2021 15:30 | Winner: Equatorial Guinea | ||||
| 1st(1st leg) | São Tomé and Príncipe | - | Togo | 0:5 (0:2) | ||
| 2nd (2nd leg) | Togo | - | São Tomé and Príncipe | 3:0 dec. | ||
| 1st(1st leg): 22/10/2021 14:00 | 2nd (2nd leg): 26/10/2021 17:00 | Winner: Togo | ||||
