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| 25/09/2021 | 13:00 | Hamburger SV | - | FSV Gütersloh 2009 | 3:2 (1:1, 1:1, 1:1) pso | |
| 13:00 | SpVgg Germania Ebing | - | SC Freiburg | 0:10 (0:3) | ||
| 14:00 | Borussia Bocholt | - | Werder Bremen | 0:1 (0:0) | ||
| 14:00 | Hannover 96 | - | Turbine Potsdam | 1:5 (0:3) | ||
| 14:00 | SG 99 Andernach | - | SC Sand | 0:1 (0:1) | ||
| 16:30 | SV 07 Elversberg | - | Bayern München | 0:6 (0:4) | ||
| 26/09/2021 | 10:00 | Hegauer FV | - | FC Carl Zeiss Jena | 0:2 (0:1) | |
| 11:00 | FSV Babelsberg 74 | - | Sportfreunde Siegen | 0:6 (0:4) | ||
| 13:00 | SV Meppen | - | SGS Essen | 0:1 (0:0) | ||
| 13:00 | RB Leipzig | - | Bayer Leverkusen | 1:3 (0:1) | ||
| 13:00 | Arminia Bielefeld | - | 1. FC Köln | 0:6 (0:1) | ||
| 13:00 | Rostocker FC | - | SV Henstedt-Ulzburg | 0:7 (0:3) | ||
| 13:00 | Wormatia Worms | - | Karlsruher SC | 0:2 (0:1) | ||
| 14:00 | Würzburger Kickers | - | 1899 Hoffenheim | 0:5 (0:3) | ||
| 14:00 | 1. FC Nürnberg | - | Eintracht Frankfurt | 0:5 (0:1) | ||
| 27/09/2021 | 17:30 | MSV Duisburg | - | VfL Wolfsburg | 1:3 (1:2) |
