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| 1st(1st leg) | WFC Lanchkhuti | - | FC Rosengård | 0:7 (0:6) | ||
| 2nd (2nd leg) | FC Rosengård | - | WFC Lanchkhuti | 10:0 (5:0) | ||
| 1st(1st leg): 09/12/2020 10:00 | 2nd (2nd leg): 16/12/2020 17:00 | Winner: FC Rosengård | ||||
| 1st(1st leg) | WFC Zhytlobud-2 Kharkiv | - | BIIK Kazygurt | 2:1 (1:0) | ||
| 2nd (2nd leg) | BIIK Kazygurt | - | WFC Zhytlobud-2 Kharkiv | 1:0 (1:0) | ||
| 1st(1st leg): 09/12/2020 11:00 | 2nd (2nd leg): 16/12/2020 06:00 | Winner: BIIK Kazygurt | ||||
| 1st(1st leg) | FK Minsk | - | Lillestrøm SK | 0:2 (0:1) | ||
| 2nd (2nd leg) | Lillestrøm SK | - | FK Minsk | 0:1 (0:0) | ||
| 1st(1st leg): 09/12/2020 11:00 | 2nd (2nd leg): 16/12/2020 17:30 | Winner: Lillestrøm SK | ||||
| 1st(1st leg) | AC Sparta Praha | - | Glasgow City FC | 2:1 (2:0) | ||
| 2nd (2nd leg) | Glasgow City FC | - | AC Sparta Praha | 0:1 (0:1) | ||
| 1st(1st leg): 09/12/2020 14:00 | 2nd (2nd leg): 16/12/2020 19:00 | Winner: AC Sparta Praha | ||||
| 1st(1st leg) | Juventus | - | Olympique Lyonnais | 2:3 (2:1) | ||
| 2nd (2nd leg) | Olympique Lyonnais | - | Juventus | 3:0 (1:0) | ||
| 1st(1st leg): 09/12/2020 14:00 | 2nd (2nd leg): 15/12/2020 18:00 | Winner: Olympique Lyonnais | ||||
| 1st(1st leg) | ŽFK Spartak Subotica | - | VfL Wolfsburg | 0:5 (0:3) | ||
| 2nd (2nd leg) | VfL Wolfsburg | - | ŽFK Spartak Subotica | 2:0 (0:0) | ||
| 1st(1st leg): 09/12/2020 14:00 | 2nd (2nd leg): 16/12/2020 17:00 | Winner: VfL Wolfsburg | ||||
| 1st(1st leg) | Kopparbergs/Göteborg FC | - | Manchester City WFC | 1:2 (1:1) | ||
| 2nd (2nd leg) | Manchester City WFC | - | Kopparbergs/Göteborg FC | 3:0 (1:0) | ||
| 1st(1st leg): 09/12/2020 15:00 | 2nd (2nd leg): 16/12/2020 15:00 | Winner: Manchester City WFC | ||||
| 1st(1st leg) | SL Benfica | - | Chelsea FC Women | 0:5 (0:4) | ||
| 2nd (2nd leg) | Chelsea FC Women | - | SL Benfica | 3:0 (1:0) | ||
| 1st(1st leg): 09/12/2020 15:00 | 2nd (2nd leg): 16/12/2020 19:00 | Winner: Chelsea FC Women | ||||
| 1st(1st leg) | ŽNK Pomurje | - | Fortuna Hjørring | 0:3 (0:1) | ||
| 2nd (2nd leg) | Fortuna Hjørring | - | ŽNK Pomurje | 3:2 (1:0) | ||
| 1st(1st leg): 09/12/2020 15:00 | 2nd (2nd leg): 16/12/2020 18:00 | Winner: Fortuna Hjørring | ||||
| 1st(1st leg) | PSV Eindhoven | - | FC Barcelona | 1:4 (0:2) | ||
| 2nd (2nd leg) | FC Barcelona | - | PSV Eindhoven | 4:1 (2:0) | ||
| 1st(1st leg): 09/12/2020 15:30 | 2nd (2nd leg): 16/12/2020 16:00 | Winner: FC Barcelona | ||||
| 1st(1st leg) | SKN St. Pölten | - | FC Zürich Frauen | 2:0 (0:0) | ||
| 2nd (2nd leg) | FC Zürich Frauen | - | SKN St. Pölten | 0:1 (0:0) | ||
| 1st(1st leg): 09/12/2020 16:00 | 2nd (2nd leg): 17/12/2020 19:15 | Winner: SKN St. Pölten | ||||
| 1st(1st leg) | Servette FCCF | - | Atlético Madrid | 2:4 (2:1) | ||
| 2nd (2nd leg) | Atlético Madrid | - | Servette FCCF | 5:0 (2:0) | ||
| 1st(1st leg): 09/12/2020 17:00 | 2nd (2nd leg): 15/12/2020 19:30 | Winner: Atlético Madrid | ||||
| 1st(1st leg) | ACF Fiorentina | - | Slavia Praha | 2:2 (1:1) | ||
| 2nd (2nd leg) | Slavia Praha | - | ACF Fiorentina | 0:1 (0:0) | ||
| 1st(1st leg): 10/12/2020 13:00 | 2nd (2nd leg): 16/12/2020 13:00 | Winner: ACF Fiorentina | ||||
| 1st(1st leg) | Górnik Łęczna | - | Paris Saint-Germain | 0:2 (0:2) | ||
| 2nd (2nd leg) | Paris Saint-Germain | - | Górnik Łęczna | 6:1 (4:0) | ||
| 1st(1st leg): 10/12/2020 16:00 | 2nd (2nd leg): 16/12/2020 13:30 | Winner: Paris Saint-Germain | ||||
| 1st(1st leg) | AFC Ajax | - | Bayern München | 1:3 (0:0) | ||
| 2nd (2nd leg) | Bayern München | - | AFC Ajax | 3:0 (1:0) | ||
| 1st(1st leg): 10/12/2020 17:00 | 2nd (2nd leg): 16/12/2020 17:00 | Winner: Bayern München | ||||
| 1st(1st leg) | Vålerenga IF | - | Brøndby IF | dnp | ||
| 2nd (2nd leg) | Brøndby IF | - | Vålerenga IF | 5:4 (0:1, 1:1, 1:1) pso | ||
| 1st(1st leg): 07/02/2021 | 2nd (2nd leg): 11/02/2021 14:00 | Winner: Brøndby IF | ||||
