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| 14/08/2018 | 17:30 | Tours FC | - | RC Lens | 0:1 (0:0) | |
| 19:00 | Havre AC | - | FC Bourg-Péronnas | 2:0 (1:0) | ||
| 19:00 | AS Nancy Lorraine | - | Red Star FC | 1:0 (1:0) | ||
| 19:00 | FC Metz | - | Grenoble Foot 38 | 2:1 (0:1) | ||
| 19:00 | US Quevilly-Rouen | - | ESTAC Troyes | 1:2 (1:2) | ||
| 19:00 | Paris FC | - | AC Ajaccio | 3:4 (0:0, 0:0) pso | ||
| 19:00 | LB Châteauroux | - | Chamois Niortais | 1:0 (1:0) | ||
| 19:00 | US Orléans | - | AS Béziers | 6:5 (0:1, 1:1) pso | ||
| 19:00 | AJ Auxerre | - | Gazélec FC Ajaccio | 3:1 (1:1) | ||
| 19:00 | Stade Lavallois | - | Clermont Foot 63 | 0:3 (0:1) | ||
| 19:00 | FC Sochaux | - | Stade Brestois 29 | 3:4 (0:1, 1:1) pso | ||
| 19:45 | Valenciennes FC | - | FC Lorient | 0:1 (0:1) |
