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| 15/12/2015 | 19:00 | Lille OSC | - | Stade Lavallois | 1:0 (0:0) | |
| 19:00 | EA Guingamp | - | OGC Nice | 4:3 (0:1, 1:1, 2:2) pso | ||
| 19:00 | FC Lorient | - | Dijon FCO | 3:0 (1:0) | ||
| 20:00 | Stade Rennais | - | Toulouse FC | 1:3 (0:2) | ||
| 16/12/2015 | 16:00 | Girondins Bordeaux | - | AS Monaco | 3:0 (1:0) | |
| 17:45 | FC Bourg-Péronnas | - | Olympique Marseille | 2:3 (1:1) | ||
| 19:00 | Olympique Lyonnais | - | Tours FC | 2:1 (1:0) | ||
| 20:00 | Paris Saint-Germain | - | AS Saint-Étienne | 1:0 (0:0) |
