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| 01/11/2000 | 14:00 | AS Nancy Lorraine | - | FC Sochaux | 1:0 (0:0) | |
| 17:00 | AS Red Star 93 | - | FC Lorient | 5:2 (4:0) | ||
| 18:00 | Havre AC | - | Stade Lavallois | 5:3 (0:0, 1:1) pso | ||
| 19:00 | Nîmes Olympique | - | Angers SCO | 4:2 (0:0) | ||
| 19:00 | Louhans-Cuiseaux | - | US Créteil-Lusitanos | 1:3 (0:1) | ||
| 19:00 | Amiens SC | - | Le Mans UC 72 | 4:2 (1:0, 2:2) aet | ||
| 19:00 | ASOA Valence | - | AS Beauvais | 2:0 (1:0) | ||
| 19:00 | FC Martigues | - | LB Châteauroux | 0:3 (0:3) | ||
| 19:00 | AS Cannes | - | Montpellier HSC | 3:0 (0:0) | ||
| 08/11/2000 | 17:30 | ES Wasquehal | - | SM Caen | 2:1 (1:1) |
