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| 19/02/1999 | 18:30 | ES Wasquehal | - | FC Metz | 0:2 (0:0) | |
| 19:00 | US Saint-Georges | - | FC Sochaux | 1:0 (0:0) | ||
| 19:00 | GFCO Ajaccio | - | ATAC Troyes | 1:3 (0:0, 1:1, 1:1) pso | ||
| 19:30 | Le Mans UC 72 | - | Stade Rennais | 2:0 (0:0) | ||
| 20/02/1999 | 14:00 | US Montagnarde | - | Paris FC | 4:0 (2:0) | |
| 16:00 | RC Lens | - | Olympique Marseille | 3:1 (2:0) | ||
| 18:00 | Dijon FCO | - | CS Sedan | 0:4 (0:0) | ||
| 19:00 | AS Angoulême Charente 92 | - | SO Châtellerault | 1:0 (1:0) | ||
| 19:00 | Clermont Foot Auvergne | - | Jura Sud | 4:1 (3:0) | ||
| 19:00 | EA Guingamp | - | RC Strasbourg | 2:1 (0:0, 1:1) aet | ||
| 19:00 | Amiens SC | - | Havre AC | 1:0 (1:0) | ||
| 19:00 | LB Châteauroux | - | Stade Lavallois | 1:2 (1:0) | ||
| 19:00 | Olympique Grand Rouen | - | FC Saint-Leu | 2:0 (1:0) | ||
| 19:30 | Paris Saint-Germain | - | FC Nantes | 4:5 (0:1, 1:1, 1:1) pso | ||
| 21/02/1999 | 16:30 | US Boulogne | - | Lille OSC | 1:2 (0:1) | |
| 27/02/1999 | 18:00 | Grenoble Foot 38 | - | Nîmes Olympique | 2:3 (1:0, 2:2) aet |
