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| 1st(1st leg) | HJK Helsinki | - | Silkeborg IF | 1:0 (0:0) | ||
| 2nd (2nd leg) | Silkeborg IF | - | HJK Helsinki | 1:1 (0:1) | ||
| 1st(1st leg): 18/08/2022 17:00 | 2nd (2nd leg): 25/08/2022 17:30 | Winner: HJK Helsinki | ||||
| 1st(1st leg) | Ferencvárosi TC | - | Shamrock Rovers | 4:0 (2:0) | ||
| 2nd (2nd leg) | Shamrock Rovers | - | Ferencvárosi TC | 1:0 (0:0) | ||
| 1st(1st leg): 18/08/2022 17:30 | 2nd (2nd leg): 25/08/2022 20:00 | Winner: Ferencvárosi TC | ||||
| 1st(1st leg) | FC Zürich | - | Heart of Midlothian | 2:1 (2:1) | ||
| 2nd (2nd leg) | Heart of Midlothian | - | FC Zürich | 0:1 (0:0) | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 20:00 | Winner: FC Zürich | ||||
| 1st(1st leg) | Malmö FF | - | Sivasspor | 3:1 (2:1) | ||
| 2nd (2nd leg) | Sivasspor | - | Malmö FF | 0:2 (0:0) | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: Malmö FF | ||||
| 1st(1st leg) | Apollon Limassol | - | Olympiakos Piraeus | 1:1 (1:1) | ||
| 2nd (2nd leg) | Olympiakos Piraeus | - | Apollon Limassol | 3:1 (1:0, 1:1, 1:1) pso | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 20:00 | Winner: Olympiakos Piraeus | ||||
| 1st(1st leg) | Pyunik FC | - | FC Sheriff | 0:0 (0:0) | ||
| 2nd (2nd leg) | FC Sheriff | - | Pyunik FC | 3:2 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 18/08/2022 18:00 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: FC Sheriff | ||||
| 1st(1st leg) | PFC Ludogorets Razgrad | - | FK Žalgiris | 1:0 (1:0) | ||
| 2nd (2nd leg) | FK Žalgiris | - | PFC Ludogorets Razgrad | 3:3 (2:1, 3:2) aet | ||
| 1st(1st leg): 18/08/2022 18:45 | 2nd (2nd leg): 25/08/2022 17:00 | Winner: PFC Ludogorets Razgrad | ||||
| 1st(1st leg) | SK Dnipro-1 | - | AEK Larnaca | 1:2 (0:2) | ||
| 2nd (2nd leg) | AEK Larnaca | - | SK Dnipro-1 | 3:0 (2:0) | ||
| 1st(1st leg): 18/08/2022 19:00 | 2nd (2nd leg): 25/08/2022 17:00 | Winner: AEK Larnaca | ||||
| 1st(1st leg) | KAA Gent | - | Omonia Nikosia | 0:2 (0:1) | ||
| 2nd (2nd leg) | Omonia Nikosia | - | KAA Gent | 2:0 (2:0) | ||
| 1st(1st leg): 18/08/2022 19:30 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: Omonia Nikosia | ||||
| 1st(1st leg) | Austria Wien | - | Fenerbahçe | 0:2 (0:1) | ||
| 2nd (2nd leg) | Fenerbahçe | - | Austria Wien | 4:1 (2:1) | ||
| 1st(1st leg): 18/08/2022 20:00 | 2nd (2nd leg): 25/08/2022 18:00 | Winner: Fenerbahçe | ||||
