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| 1st(1st leg) | Torpedo Kutaisi | - | PFC Ludogorets Razgrad | 0:1 (0:1) | ||
| 2nd (2nd leg) | PFC Ludogorets Razgrad | - | Torpedo Kutaisi | 4:0 (2:0) | ||
| 1st(1st leg): 23/08/2018 17:00 | 2nd (2nd leg): 30/08/2018 18:00 | Winner: PFC Ludogorets Razgrad | ||||
| 1st(1st leg) | Zenit St. Petersburg | - | Molde FK | 3:1 (0:1) | ||
| 2nd (2nd leg) | Molde FK | - | Zenit St. Petersburg | 2:1 (0:1) | ||
| 1st(1st leg): 23/08/2018 17:00 | 2nd (2nd leg): 30/08/2018 18:00 | Winner: Zenit St. Petersburg | ||||
| 1st(1st leg) | AS Trenčín | - | AEK Larnaca | 1:1 (0:0) | ||
| 2nd (2nd leg) | AEK Larnaca | - | AS Trenčín | 3:0 (2:0) | ||
| 1st(1st leg): 23/08/2018 17:30 | 2nd (2nd leg): 30/08/2018 16:30 | Winner: AEK Larnaca | ||||
| 1st(1st leg) | APOEL Nikosia | - | FK Astana | 1:0 (0:0) | ||
| 2nd (2nd leg) | FK Astana | - | APOEL Nikosia | 2:1 (1:0, 1:0, 1:0) pso | ||
| 1st(1st leg): 23/08/2018 18:00 | 2nd (2nd leg): 30/08/2018 15:00 | Winner: FK Astana | ||||
| 1st(1st leg) | FK Sūduva | - | Celtic FC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Celtic FC | - | FK Sūduva | 3:0 (1:0) | ||
| 1st(1st leg): 23/08/2018 18:00 | 2nd (2nd leg): 30/08/2018 20:00 | Winner: Celtic FC | ||||
| 1st(1st leg) | FC Sheriff | - | Qarabağ FK | 1:0 (1:0) | ||
| 2nd (2nd leg) | Qarabağ FK | - | FC Sheriff | 3:0 (2:0) | ||
| 1st(1st leg): 23/08/2018 18:00 | 2nd (2nd leg): 30/08/2018 18:00 | Winner: Qarabağ FK | ||||
| 1st(1st leg) | Sigma Olomouc | - | Sevilla FC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Sevilla FC | - | Sigma Olomouc | 3:0 (2:0) | ||
| 1st(1st leg): 23/08/2018 18:00 | 2nd (2nd leg): 30/08/2018 20:45 | Winner: Sevilla FC | ||||
| 1st(1st leg) | Sarpsborg 08 | - | Maccabi Tel Aviv | 3:1 (2:1) | ||
| 2nd (2nd leg) | Maccabi Tel Aviv | - | Sarpsborg 08 | 2:1 (0:0) | ||
| 1st(1st leg): 23/08/2018 18:05 | 2nd (2nd leg): 30/08/2018 18:00 | Winner: Sarpsborg 08 | ||||
| 1st(1st leg) | Malmö FF | - | FC Midtjylland | 2:2 (2:0) | ||
| 2nd (2nd leg) | FC Midtjylland | - | Malmö FF | 0:2 (0:1) | ||
| 1st(1st leg): 23/08/2018 18:15 | 2nd (2nd leg): 30/08/2018 18:15 | Winner: Malmö FF | ||||
| 1st(1st leg) | F91 Dudelange | - | CFR Cluj | 2:0 (0:0) | ||
| 2nd (2nd leg) | CFR Cluj | - | F91 Dudelange | 2:3 (0:0) | ||
| 1st(1st leg): 23/08/2018 19:00 | 2nd (2nd leg): 30/08/2018 18:00 | Winner: F91 Dudelange | ||||
| 1st(1st leg) | FC Basel 1893 | - | Apollon Limassol | 3:2 (1:0) | ||
| 2nd (2nd leg) | Apollon Limassol | - | FC Basel 1893 | 1:0 (0:0) | ||
| 1st(1st leg): 23/08/2018 19:00 | 2nd (2nd leg): 30/08/2018 18:00 | Winner: Apollon Limassol | ||||
| 1st(1st leg) | Atalanta | - | FC København | 0:0 (0:0) | ||
| 2nd (2nd leg) | FC København | - | Atalanta | 4:3 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 23/08/2018 19:00 | 2nd (2nd leg): 30/08/2018 17:30 | Winner: FC København | ||||
| 1st(1st leg) | Olympiakos Piraeus | - | Burnley FC | 3:1 (1:1) | ||
| 2nd (2nd leg) | Burnley FC | - | Olympiakos Piraeus | 1:1 (0:0) | ||
| 1st(1st leg): 23/08/2018 19:00 | 2nd (2nd leg): 30/08/2018 19:45 | Winner: Olympiakos Piraeus | ||||
| 1st(1st leg) | Olimpija Ljubljana | - | Spartak Trnava | 0:2 (0:2) | ||
| 2nd (2nd leg) | Spartak Trnava | - | Olimpija Ljubljana | 1:1 (1:1) | ||
| 1st(1st leg): 23/08/2018 19:30 | 2nd (2nd leg): 30/08/2018 19:30 | Winner: Spartak Trnava | ||||
| 1st(1st leg) | Rapid Wien | - | FCSB | 3:1 (2:0) | ||
| 2nd (2nd leg) | FCSB | - | Rapid Wien | 2:1 (2:0) | ||
| 1st(1st leg): 23/08/2018 19:30 | 2nd (2nd leg): 30/08/2018 19:30 | Winner: Rapid Wien | ||||
| 1st(1st leg) | Partizan | - | Beşiktaş | 1:1 (1:1) | ||
| 2nd (2nd leg) | Beşiktaş | - | Partizan | 3:0 (2:0) | ||
| 1st(1st leg): 23/08/2018 19:30 | 2nd (2nd leg): 30/08/2018 19:00 | Winner: Beşiktaş | ||||
| 1st(1st leg) | KRC Genk | - | Brøndby IF | 5:2 (2:0) | ||
| 2nd (2nd leg) | Brøndby IF | - | KRC Genk | 2:4 (1:2) | ||
| 1st(1st leg): 23/08/2018 19:30 | 2nd (2nd leg): 30/08/2018 19:30 | Winner: KRC Genk | ||||
| 1st(1st leg) | Zorya Lugansk | - | RB Leipzig | 0:0 (0:0) | ||
| 2nd (2nd leg) | RB Leipzig | - | Zorya Lugansk | 3:2 (1:1) | ||
| 1st(1st leg): 23/08/2018 19:30 | 2nd (2nd leg): 30/08/2018 17:30 | Winner: RB Leipzig | ||||
| 1st(1st leg) | Rosenborg BK | - | KF Shkëndija 79 | 3:1 (3:0) | ||
| 2nd (2nd leg) | KF Shkëndija 79 | - | Rosenborg BK | 0:2 (0:0) | ||
| 1st(1st leg): 23/08/2018 19:45 | 2nd (2nd leg): 30/08/2018 19:15 | Winner: Rosenborg BK | ||||
| 1st(1st leg) | Rangers FC | - | FK Ufa | 1:0 (1:0) | ||
| 2nd (2nd leg) | FK Ufa | - | Rangers FC | 1:1 (1:1) | ||
| 1st(1st leg): 23/08/2018 19:45 | 2nd (2nd leg): 30/08/2018 15:00 | Winner: Rangers FC | ||||
| 1st(1st leg) | KAA Gent | - | Girondins Bordeaux | 0:0 (0:0) | ||
| 2nd (2nd leg) | Girondins Bordeaux | - | KAA Gent | 2:0 (1:0) | ||
| 1st(1st leg): 23/08/2018 19:45 | 2nd (2nd leg): 30/08/2018 19:45 | Winner: Girondins Bordeaux | ||||
