1st(1st leg) Tobyl Kostanay - Zrinjski Mostar 1:2 (1:0)
2nd (2nd leg) Zrinjski Mostar - Tobyl Kostanay 2:1 (1:0)
1st(1st leg): 01/07/2010 15:00 2nd (2nd leg): 08/07/2010 18:30 Winner: Zrinjski Mostar
1st(1st leg) Ulisses FC - Bnei Yehuda Tel Aviv 0:0 (0:0)
2nd (2nd leg) Bnei Yehuda Tel Aviv - Ulisses FC 1:0 (1:0)
1st(1st leg): 01/07/2010 15:00 2nd (2nd leg): 08/07/2010 17:00 Winner: Bnei Yehuda Tel Aviv
1st(1st leg) Dinamo Tbilisi - FC Flora 2:1 (1:1)
2nd (2nd leg) FC Flora - Dinamo Tbilisi 0:0 (0:0)
1st(1st leg): 01/07/2010 15:00 2nd (2nd leg): 08/07/2010 16:45 Winner: Dinamo Tbilisi
1st(1st leg) KF Laçi - Dnepr Mogilev 1:1 (1:0)
2nd (2nd leg) Dnepr Mogilev - KF Laçi 7:1 (3:0)
1st(1st leg): 01/07/2010 15:30 2nd (2nd leg): 08/07/2010 17:00 Winner: Dnepr Mogilev
1st(1st leg) FK Rabotnički - FC Lusitanos 5:0 (2:0)
2nd (2nd leg) FC Lusitanos - FK Rabotnički 0:6 (0:3)
1st(1st leg): 01/07/2010 16:00 2nd (2nd leg): 08/07/2010 18:15 Winner: FK Rabotnički
1st(1st leg) JK Narva Trans - MyPa-47 0:2 (0:0)
2nd (2nd leg) MyPa-47 - JK Narva Trans 5:0 (0:0)
1st(1st leg): 01/07/2010 16:00 2nd (2nd leg): 08/07/2010 17:00 Winner: MyPa-47
1st(1st leg) Shakter Karaganda - Ruch Chorzów 1:2 (1:1)
2nd (2nd leg) Ruch Chorzów - Shakter Karaganda 1:0 (0:0)
1st(1st leg): 01/07/2010 16:00 2nd (2nd leg): 08/07/2010 19:30 Winner: Ruch Chorzów
1st(1st leg) KF Tiranë - Zalaegerszegi TE 0:0 (0:0)
2nd (2nd leg) Zalaegerszegi TE - KF Tiranë 0:1 (0:0, 0:0) aet
1st(1st leg): 01/07/2010 16:30 2nd (2nd leg): 08/07/2010 18:00 Winner: KF Tiranë
1st(1st leg) Torpedo Zhodino - Fylkir Reykjavík 3:0 (0:0)
2nd (2nd leg) Fylkir Reykjavík - Torpedo Zhodino 1:3 (1:1)
1st(1st leg): 01/07/2010 16:30 2nd (2nd leg): 08/07/2010 20:00 Winner: Torpedo Zhodino
1st(1st leg) FK Zeta - Dacia Chişinău 1:1 (0:1)
2nd (2nd leg) Dacia Chişinău - FK Zeta 0:0 (0:0)
1st(1st leg): 01/07/2010 16:30 2nd (2nd leg): 08/07/2010 17:30 Winner: Dacia Chişinău
1st(1st leg) FC Olimpia Bălți - Khazar Lankaran 0:0 (0:0)
2nd (2nd leg) Khazar Lankaran - FC Olimpia Bălți 1:1 (0:1)
1st(1st leg): 01/07/2010 17:00 2nd (2nd leg): 08/07/2010 17:00 Winner: FC Olimpia Bălți
1st(1st leg) FC Zestafoni - SC Faetano 5:0 (3:0)
2nd (2nd leg) SC Faetano - FC Zestafoni 0:0 (0:0)
1st(1st leg): 01/07/2010 17:00 2nd (2nd leg): 08/07/2010 19:30 Winner: FC Zestafoni
1st(1st leg) TPS Turku - Port Talbot Town 3:1 (3:0)
2nd (2nd leg) Port Talbot Town - TPS Turku 0:4 (0:2)
1st(1st leg): 01/07/2010 17:00 2nd (2nd leg): 08/07/2010 18:15 Winner: TPS Turku
1st(1st leg) FC Nitra - Győri ETO FC 2:2 (1:1)
2nd (2nd leg) Győri ETO FC - FC Nitra 3:1 (1:1)
1st(1st leg): 01/07/2010 17:00 2nd (2nd leg): 08/07/2010 17:30 Winner: Győri ETO FC
1st(1st leg) Qarabağ FK - Metalurg Skopje 4:1 (2:0)
2nd (2nd leg) Metalurg Skopje - Qarabağ FK 1:1 (0:0)
1st(1st leg): 01/07/2010 17:00 2nd (2nd leg): 08/07/2010 16:00 Winner: Qarabağ FK
1st(1st leg) HNK Šibenik - Sliema Wanderers 0:0 (0:0)
2nd (2nd leg) Sliema Wanderers - HNK Šibenik 0:3 (0:0)
1st(1st leg): 01/07/2010 17:30 2nd (2nd leg): 08/07/2010 16:30 Winner: HNK Šibenik
1st(1st leg) UE Santa Coloma - FK Mogren Budva 0:3 (0:1)
2nd (2nd leg) FK Mogren Budva - UE Santa Coloma 2:0 (2:0)
1st(1st leg): 01/07/2010 18:00 2nd (2nd leg): 08/07/2010 16:30 Winner: FK Mogren Budva
1st(1st leg) Anorthosis Famagusta - FC Banants 3:0 (2:0)
2nd (2nd leg) FC Banants - Anorthosis Famagusta 0:1 (0:1)
1st(1st leg): 01/07/2010 18:00 2nd (2nd leg): 08/07/2010 16:00 Winner: Anorthosis Famagusta
1st(1st leg) Randers FC - F91 Dudelange 6:1 (3:0)
2nd (2nd leg) F91 Dudelange - Randers FC 2:1 (1:1)
1st(1st leg): 01/07/2010 18:00 2nd (2nd leg): 08/07/2010 17:30 Winner: Randers FC
1st(1st leg) Portadown FC - Skonto FC 1:1 (1:0)
2nd (2nd leg) Skonto FC - Portadown FC 0:1 (0:1)
1st(1st leg): 01/07/2010 18:30 2nd (2nd leg): 08/07/2010 17:00 Winner: Portadown FC
1st(1st leg) CS Grevenmacher - Dundalk FC 3:3 (0:1)
2nd (2nd leg) Dundalk FC - CS Grevenmacher 2:1 (2:0)
1st(1st leg): 01/07/2010 18:30 2nd (2nd leg): 08/07/2010 19:00 Winner: Dundalk FC
1st(1st leg) NSÍ Runavík - Gefle IF 0:2 (0:1)
2nd (2nd leg) Gefle IF - NSÍ Runavík 2:1 (1:0)
1st(1st leg): 01/07/2010 19:00 2nd (2nd leg): 08/07/2010 18:00 Winner: Gefle IF
1st(1st leg) Llanelli AFC - Tauras Tauragė 2:2 (1:2)
2nd (2nd leg) Tauras Tauragė - Llanelli AFC 3:2 (2:2, 2:2) aet
1st(1st leg): 01/07/2010 19:05 2nd (2nd leg): 08/07/2010 16:00 Winner: Tauras Tauragė
1st(1st leg) Olimpija Ljubljana - Široki Brijeg 0:2 (0:1)
2nd (2nd leg) Široki Brijeg - Olimpija Ljubljana 3:0 (0:0)
1st(1st leg): 01/07/2010 19:45 2nd (2nd leg): 08/07/2010 19:30 Winner: Široki Brijeg
1st(1st leg) Kalmar FF - EB/Streymur 1:0 (0:0)
2nd (2nd leg) EB/Streymur - Kalmar FF 0:3 (0:1)
1st(1st leg): 01/07/2010 20:00 2nd (2nd leg): 08/07/2010 19:00 Winner: Kalmar FF
1st(1st leg) KR Reykjavík - Glentoran FC 3:0 (2:0)
2nd (2nd leg) Glentoran FC - KR Reykjavík 2:2 (1:1)
1st(1st leg): 01/07/2010 20:15 2nd (2nd leg): 08/07/2010 19:30 Winner: KR Reykjavík