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| 1st(1st leg) | Fenerbahçe | - | RSC Anderlecht | 3:0 (2:0) | ||
| 2nd (2nd leg) | RSC Anderlecht | - | Fenerbahçe | 2:2 (1:1) | ||
| 1st(1st leg): 13/02/2025 17:45 | 2nd (2nd leg): 20/02/2025 20:00 | Winner: Fenerbahçe | ||||
| 1st(1st leg) | Union Saint-Gilloise | - | AFC Ajax | 0:2 (0:0) | ||
| 2nd (2nd leg) | AFC Ajax | - | Union Saint-Gilloise | 1:2 (0:2, 0:2) aet | ||
| 1st(1st leg): 13/02/2025 17:45 | 2nd (2nd leg): 20/02/2025 20:00 | Winner: AFC Ajax | ||||
| 1st(1st leg) | FC Midtjylland | - | Real Sociedad | 1:2 (1:2) | ||
| 2nd (2nd leg) | Real Sociedad | - | FC Midtjylland | 5:2 (3:2) | ||
| 1st(1st leg): 13/02/2025 17:45 | 2nd (2nd leg): 20/02/2025 20:00 | Winner: Real Sociedad | ||||
| 1st(1st leg) | Ferencvárosi TC | - | Viktoria Plzeň | 1:0 (1:0) | ||
| 2nd (2nd leg) | Viktoria Plzeň | - | Ferencvárosi TC | 3:0 (3:0) | ||
| 1st(1st leg): 13/02/2025 17:45 | 2nd (2nd leg): 20/02/2025 20:00 | Winner: Viktoria Plzeň | ||||
| 1st(1st leg) | FC Twente | - | FK Bodø/Glimt | 2:1 (1:0) | ||
| 2nd (2nd leg) | FK Bodø/Glimt | - | FC Twente | 5:2 (0:1, 3:2) aet | ||
| 1st(1st leg): 13/02/2025 20:00 | 2nd (2nd leg): 20/02/2025 17:45 | Winner: FK Bodø/Glimt | ||||
| 1st(1st leg) | PAOK Saloniki | - | FCSB | 1:2 (1:0) | ||
| 2nd (2nd leg) | FCSB | - | PAOK Saloniki | 2:0 (1:0) | ||
| 1st(1st leg): 13/02/2025 20:00 | 2nd (2nd leg): 20/02/2025 17:45 | Winner: FCSB | ||||
| 1st(1st leg) | AZ Alkmaar | - | Galatasaray | 4:1 (2:1) | ||
| 2nd (2nd leg) | Galatasaray | - | AZ Alkmaar | 2:2 (0:1) | ||
| 1st(1st leg): 13/02/2025 20:00 | 2nd (2nd leg): 20/02/2025 17:45 | Winner: AZ Alkmaar | ||||
| 1st(1st leg) | FC Porto | - | AS Roma | 1:1 (0:1) | ||
| 2nd (2nd leg) | AS Roma | - | FC Porto | 3:2 (2:1) | ||
| 1st(1st leg): 13/02/2025 20:00 | 2nd (2nd leg): 20/02/2025 17:45 | Winner: AS Roma | ||||
