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| 1st(1st leg) | Feyenoord | - | AS Roma | 1:0 (0:0) | ||
| 2nd (2nd leg) | AS Roma | - | Feyenoord | 4:1 (0:0, 2:1) aet | ||
| 1st(1st leg): 13/04/2023 17:45 | 2nd (2nd leg): 20/04/2023 20:00 | Winner: AS Roma | ||||
| 1st(1st leg) | Manchester United | - | Sevilla FC | 2:2 (2:0) | ||
| 2nd (2nd leg) | Sevilla FC | - | Manchester United | 3:0 (1:0) | ||
| 1st(1st leg): 13/04/2023 20:00 | 2nd (2nd leg): 20/04/2023 20:00 | Winner: Sevilla FC | ||||
| 1st(1st leg) | Juventus | - | Sporting CP | 1:0 (0:0) | ||
| 2nd (2nd leg) | Sporting CP | - | Juventus | 1:1 (1:1) | ||
| 1st(1st leg): 13/04/2023 20:00 | 2nd (2nd leg): 20/04/2023 20:00 | Winner: Juventus | ||||
| 1st(1st leg) | Bayer Leverkusen | - | Union Saint-Gilloise | 1:1 (0:0) | ||
| 2nd (2nd leg) | Union Saint-Gilloise | - | Bayer Leverkusen | 1:4 (0:2) | ||
| 1st(1st leg): 13/04/2023 20:00 | 2nd (2nd leg): 20/04/2023 20:00 | Winner: Bayer Leverkusen | ||||
