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| 1st(1st leg) | RB Leipzig | - | Atalanta | 1:1 (0:1) | ||
| 2nd (2nd leg) | Atalanta | - | RB Leipzig | 0:2 (0:1) | ||
| 1st(1st leg): 07/04/2022 17:45 | 2nd (2nd leg): 14/04/2022 17:45 | Winner: RB Leipzig | ||||
| 1st(1st leg) | Eintracht Frankfurt | - | FC Barcelona | 1:1 (0:0) | ||
| 2nd (2nd leg) | FC Barcelona | - | Eintracht Frankfurt | 2:3 (0:2) | ||
| 1st(1st leg): 07/04/2022 20:00 | 2nd (2nd leg): 14/04/2022 20:00 | Winner: Eintracht Frankfurt | ||||
| 1st(1st leg) | West Ham United | - | Olympique Lyonnais | 1:1 (0:0) | ||
| 2nd (2nd leg) | Olympique Lyonnais | - | West Ham United | 0:3 (0:2) | ||
| 1st(1st leg): 07/04/2022 20:00 | 2nd (2nd leg): 14/04/2022 20:00 | Winner: West Ham United | ||||
| 1st(1st leg) | Sporting Braga | - | Rangers FC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Rangers FC | - | Sporting Braga | 3:1 (2:0, 2:1) aet | ||
| 1st(1st leg): 07/04/2022 20:00 | 2nd (2nd leg): 14/04/2022 20:00 | Winner: Rangers FC | ||||
