1st(1st leg) AZ Alkmaar - Valencia CF 2:1 (1:0)
2nd (2nd leg) Valencia CF - AZ Alkmaar 4:0 (2:0)
1st(1st leg): 29/03/2012 20:05 2nd (2nd leg): 05/04/2012 20:05 Winner: Valencia CF
1st(1st leg) FC Schalke 04 - Athletic Club 2:4 (1:1)
2nd (2nd leg) Athletic Club - FC Schalke 04 2:2 (1:1)
1st(1st leg): 29/03/2012 20:05 2nd (2nd leg): 05/04/2012 20:05 Winner: Athletic Club
1st(1st leg) Sporting CP - Metalist Kharkiv 2:1 (0:0)
2nd (2nd leg) Metalist Kharkiv - Sporting CP 1:1 (0:1)
1st(1st leg): 29/03/2012 20:05 2nd (2nd leg): 05/04/2012 20:05 Winner: Sporting CP
1st(1st leg) Atlético Madrid - Hannover 96 2:1 (1:1)
2nd (2nd leg) Hannover 96 - Atlético Madrid 1:2 (0:0)
1st(1st leg): 29/03/2012 20:05 2nd (2nd leg): 05/04/2012 20:05 Winner: Atlético Madrid