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| 1st(1st leg) | Lazio Roma | - | AZ Alkmaar | 1:2 (1:1) | ||
| 2nd (2nd leg) | AZ Alkmaar | - | Lazio Roma | 2:1 (1:1) | ||
| 1st(1st leg): 07/03/2023 17:45 | 2nd (2nd leg): 16/03/2023 20:00 | Winner: AZ Alkmaar | ||||
| 1st(1st leg) | AEK Larnaca | - | West Ham United | 0:2 (0:2) | ||
| 2nd (2nd leg) | West Ham United | - | AEK Larnaca | 4:0 (1:0) | ||
| 1st(1st leg): 09/03/2023 17:45 | 2nd (2nd leg): 16/03/2023 20:00 | Winner: West Ham United | ||||
| 1st(1st leg) | FC Sheriff | - | OGC Nice | 0:1 (0:1) | ||
| 2nd (2nd leg) | OGC Nice | - | FC Sheriff | 3:1 (1:0) | ||
| 1st(1st leg): 09/03/2023 17:45 | 2nd (2nd leg): 16/03/2023 20:00 | Winner: OGC Nice | ||||
| 1st(1st leg) | RSC Anderlecht | - | Villarreal CF | 1:1 (0:1) | ||
| 2nd (2nd leg) | Villarreal CF | - | RSC Anderlecht | 0:1 (0:0) | ||
| 1st(1st leg): 09/03/2023 17:45 | 2nd (2nd leg): 16/03/2023 20:00 | Winner: RSC Anderlecht | ||||
| 1st(1st leg) | ACF Fiorentina | - | Sivasspor | 1:0 (0:0) | ||
| 2nd (2nd leg) | Sivasspor | - | ACF Fiorentina | 1:4 (1:1) | ||
| 1st(1st leg): 09/03/2023 20:00 | 2nd (2nd leg): 16/03/2023 17:45 | Winner: ACF Fiorentina | ||||
| 1st(1st leg) | Lech Poznań | - | Djurgårdens IF | 2:0 (1:0) | ||
| 2nd (2nd leg) | Djurgårdens IF | - | Lech Poznań | 0:3 (0:0) | ||
| 1st(1st leg): 09/03/2023 20:00 | 2nd (2nd leg): 16/03/2023 17:45 | Winner: Lech Poznań | ||||
| 1st(1st leg) | FC Basel 1893 | - | Slovan Bratislava | 2:2 (2:1) | ||
| 2nd (2nd leg) | Slovan Bratislava | - | FC Basel 1893 | 1:4 (2:0, 2:2, 2:2) pso | ||
| 1st(1st leg): 09/03/2023 20:00 | 2nd (2nd leg): 16/03/2023 17:45 | Winner: FC Basel 1893 | ||||
| 1st(1st leg) | KAA Gent | - | İstanbul Başakşehir | 1:1 (1:1) | ||
| 2nd (2nd leg) | İstanbul Başakşehir | - | KAA Gent | 1:4 (0:4) | ||
| 1st(1st leg): 09/03/2023 20:00 | 2nd (2nd leg): 15/03/2023 17:00 | Winner: KAA Gent | ||||
