1st(1st leg) PAOK Saloniki - KAA Gent 1:0 (0:0)
2nd (2nd leg) KAA Gent - PAOK Saloniki 1:2 (1:1)
1st(1st leg): 10/03/2022 17:45 2nd (2nd leg): 17/03/2022 20:00 Winner: PAOK Saloniki
1st(1st leg) Vitesse - AS Roma 0:1 (0:1)
2nd (2nd leg) AS Roma - Vitesse 1:1 (0:0)
1st(1st leg): 10/03/2022 17:45 2nd (2nd leg): 17/03/2022 20:00 Winner: AS Roma
1st(1st leg) Slavia Praha - LASK 4:1 (2:0)
2nd (2nd leg) LASK - Slavia Praha 4:3 (1:2)
1st(1st leg): 10/03/2022 17:45 2nd (2nd leg): 17/03/2022 20:00 Winner: Slavia Praha
1st(1st leg) Partizan - Feyenoord 2:5 (1:1)
2nd (2nd leg) Feyenoord - Partizan 3:1 (1:0)
1st(1st leg): 10/03/2022 17:45 2nd (2nd leg): 17/03/2022 20:00 Winner: Feyenoord
1st(1st leg) Olympique Marseille - FC Basel 1893 2:1 (1:0)
2nd (2nd leg) FC Basel 1893 - Olympique Marseille 1:2 (0:0)
1st(1st leg): 10/03/2022 20:00 2nd (2nd leg): 17/03/2022 17:45 Winner: Olympique Marseille
1st(1st leg) Leicester City - Stade Rennais 2:0 (1:0)
2nd (2nd leg) Stade Rennais - Leicester City 2:1 (1:0)
1st(1st leg): 10/03/2022 20:00 2nd (2nd leg): 17/03/2022 17:45 Winner: Leicester City
1st(1st leg) PSV Eindhoven - FC København 4:4 (1:3)
2nd (2nd leg) FC København - PSV Eindhoven 0:4 (0:2)
1st(1st leg): 10/03/2022 20:00 2nd (2nd leg): 17/03/2022 17:45 Winner: PSV Eindhoven
1st(1st leg) FK Bodø/Glimt - AZ Alkmaar 2:1 (1:0)
2nd (2nd leg) AZ Alkmaar - FK Bodø/Glimt 2:2 (2:1, 2:1) aet
1st(1st leg): 10/03/2022 20:00 2nd (2nd leg): 17/03/2022 17:45 Winner: FK Bodø/Glimt