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| 1st(1st leg) | Real Madrid Castilla | - | FC Cartagena | 3:1 (3:0) | ||
| 2nd (2nd leg) | FC Cartagena | - | Real Madrid Castilla | 2:0 (2:0) | ||
| 1st(1st leg): 25/05/2019 17:00 | 2nd (2nd leg): 02/06/2019 18:30 | Winner: FC Cartagena | ||||
| 1st(1st leg) | CD Badajoz | - | UD Logroñés | 0:1 (0:0) | ||
| 2nd (2nd leg) | UD Logroñés | - | CD Badajoz | 3:3 (2:3) | ||
| 1st(1st leg): 25/05/2019 18:00 | 2nd (2nd leg): 02/06/2019 18:30 | Winner: UD Logroñés | ||||
| 1st(1st leg) | Atlético Madrid B | - | CD Mirandés | 0:0 (0:0) | ||
| 2nd (2nd leg) | CD Mirandés | - | Atlético Madrid B | 2:1 (0:1) | ||
| 1st(1st leg): 26/05/2019 11:00 | 2nd (2nd leg): 02/06/2019 18:30 | Winner: CD Mirandés | ||||
| 1st(1st leg) | Barakaldo CF | - | Hércules CF | 1:1 (1:0) | ||
| 2nd (2nd leg) | Hércules CF | - | Barakaldo CF | 0:0 (0:0) | ||
| 1st(1st leg): 26/05/2019 17:00 | 2nd (2nd leg): 02/06/2019 18:30 | Winner: Hércules CF | ||||
| 1st(1st leg) | Villarreal CF B | - | UD Melilla | 0:2 (0:0) | ||
| 2nd (2nd leg) | UD Melilla | - | Villarreal CF B | 2:1 (0:1) | ||
| 1st(1st leg): 26/05/2019 17:30 | 2nd (2nd leg): 02/06/2019 18:30 | Winner: UD Melilla | ||||
| 1st(1st leg) | UE Cornellà | - | SD Ponferradina | 2:1 (0:0) | ||
| 2nd (2nd leg) | SD Ponferradina | - | UE Cornellà | 2:0 (1:0) | ||
| 1st(1st leg): 26/05/2019 18:15 | 2nd (2nd leg): 02/06/2019 19:00 | Winner: SD Ponferradina | ||||
