1st(1st leg) Sporting Gijón - Valencia CF 2:1 (1:1)
2nd (2nd leg) Valencia CF - Sporting Gijón 3:0 (0:0)
1st(1st leg): 08/01/2019 20:30 2nd (2nd leg): 15/01/2019 20:30 Winner: Valencia CF
1st(1st leg) Girona FC - Atlético Madrid 1:1 (1:1)
2nd (2nd leg) Atlético Madrid - Girona FC 3:3 (1:1)
1st(1st leg): 09/01/2019 18:30 2nd (2nd leg): 16/01/2019 18:30 Winner: Girona FC
1st(1st leg) Getafe CF - Real Valladolid 1:0 (0:0)
2nd (2nd leg) Real Valladolid - Getafe CF 1:1 (0:1)
1st(1st leg): 09/01/2019 19:30 2nd (2nd leg): 15/01/2019 18:30 Winner: Getafe CF
1st(1st leg) Villarreal CF - Espanyol Barcelona 2:2 (0:1)
2nd (2nd leg) Espanyol Barcelona - Villarreal CF 3:1 (2:1)
1st(1st leg): 09/01/2019 19:30 2nd (2nd leg): 17/01/2019 19:30 Winner: Espanyol Barcelona
1st(1st leg) Real Madrid - CD Leganés 3:0 (1:0)
2nd (2nd leg) CD Leganés - Real Madrid 1:0 (1:0)
1st(1st leg): 09/01/2019 20:30 2nd (2nd leg): 16/01/2019 20:30 Winner: Real Madrid
1st(1st leg) Athletic Club - Sevilla FC 1:3 (0:1)
2nd (2nd leg) Sevilla FC - Athletic Club 0:1 (0:0)
1st(1st leg): 10/01/2019 18:30 2nd (2nd leg): 16/01/2019 19:30 Winner: Sevilla FC
1st(1st leg) Real Betis - Real Sociedad 0:0 (0:0)
2nd (2nd leg) Real Sociedad - Real Betis 2:2 (1:1)
1st(1st leg): 10/01/2019 19:30 2nd (2nd leg): 17/01/2019 18:30 Winner: Real Betis
1st(1st leg) Levante UD - FC Barcelona 2:1 (2:0)
2nd (2nd leg) FC Barcelona - Levante UD 3:0 (2:0)
1st(1st leg): 10/01/2019 20:30 2nd (2nd leg): 17/01/2019 20:30 Winner: FC Barcelona